Adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC9A2, ENKUR, and RPS12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC9A2 grouped by Adenylate cyclase-activating adrenergic receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC9A2 →	+1.294	+0.727	.002	.002	3	5
SOFT_TISSUE	ENKUR →	-0.947	-1.293	.009	<.001	3	4
LUNG_SCLC	RPS12 →	+0.782	+0.990	.002	.008	3	4
CNS	KIAA0753 →	-0.475	-0.697	.004	.005	3	4
OVARY	NDUFA1 →	+0.774	+1.183	.004	<.001	3	4
OVARY	IRF3 →	+0.823	+1.299	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC9A2 by Adenylate cyclase-activating adrenergic receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →