Adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC8C, CRB1, and FLG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating adrenergic receptor signaling pathway activity versus LRRC8C in LUNG_NSCLC_LUAD (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LRRC8C →	+1.124	+0.271	<.001	.009	3	3
CNS	CRB1 →	+0.072	+0.269	.006	.009	2	3
LUNG_NSCLC_LUAD	FLG →	+1.044	+0.271	.001	.009	3	2
LUNG_NSCLC_LUAD	NAT8 →	+0.093	+0.344	.001	.007	3	2
LUNG_NSCLC_LUAD	FCER1A →	-0.046	-0.305	.002	.006	3	2
LUNG_NSCLC_LUAD	MAEA →	-0.713	-0.271	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071880 vs LRRC8C — LUNG_NSCLC_LUAD

Explore this scatter interactively →