Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAP2, MARCKS_S101, and CGN_S155, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway activity versus STAP2 in UCEC (Pearson r = -0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAP2 →	-0.420	-0.052	<.001	.006	3	7
LSCC	MARCKS_S101 →	+0.548	+0.074	.001	<.001	3	7
LUAD	CGN_S155 →	-0.639	-0.050	.001	.001	3	7
GBM	GNG2 →	+0.546	+0.030	<.001	.007	3	7
HNSC	ELMO1 →	+0.471	+0.075	<.001	.001	3	7
LSCC	STAB1 →	+0.327	+0.057	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071878 vs STAP2 — UCEC

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