Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFAS, CES2, and KDELR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PFAS grouped by Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PFAS →	-0.960	-1.975	.008	<.001	2	6
BLOOD_Leukemia	CES2 →	-0.666	-1.243	.006	<.001	3	5
LARGE_INTESTINE	KDELR2 →	+0.592	+0.924	.008	.005	3	4
LARGE_INTESTINE	SPRYD4 →	-0.369	-1.109	.007	.008	3	4
LARGE_INTESTINE	RAB7A →	+0.426	+0.890	.001	.001	3	4
BONE	CBWD5 →	+0.976	+1.676	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PFAS by Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway activity — BLOOD_Lymphoma

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