Response to catecholamine

Across TCGA patient cohorts, RNA activity of the Response to catecholamine pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XPO1, NUP133, and NUP160, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to catecholamine activity versus XPO1 in LSCC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XPO1 →	-0.282	-0.039	<.001	<.001	3	7
GBM	NUP133 →	-0.156	-0.048	.001	<.001	3	7
BRCA	NUP160 →	-0.205	-0.024	.002	<.001	3	7
UCEC	RBBP6_S873 →	-0.527	-0.053	<.001	<.001	3	7
LSCC	DHX9 →	-0.255	-0.039	<.001	<.001	3	7
GBM	SF3B1 →	-0.196	-0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071869 vs XPO1 — LSCC

Explore this scatter interactively →