Response to catecholamine

Across TCGA cell cohorts, RNA activity of the Response to catecholamine pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIT2, TSPAN2, and CCN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to catecholamine activity versus IFIT2 in PANCREAS (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	IFIT2 →	+2.472	+0.309	.005	.008	3	8
UPPER_AERODIGESTIVE_TRACT	TSPAN2 →	+1.470	+0.208	.007	.008	3	7
LIVER	CCN1 →	+3.236	+0.442	.001	.001	3	7
OESOPHAGUS	NEK3 →	-2.118	-0.312	.003	.003	3	7
LARGE_INTESTINE	IDS →	+1.507	+0.408	<.001	.008	3	7
OVARY	SAMD9 →	+1.525	+0.273	.002	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071869 vs IFIT2 — PANCREAS

Explore this scatter interactively →