Regulation of apoptotic process in bone marrow cell

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic process in bone marrow cell pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEF1, PLK2, and LEF1-AS1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic process in bone marrow cell activity versus LEF1 in ACC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	LEF1 →	+2.163	+0.118	<.001	<.001	3	27
SCLC	PLK2 →	+3.168	+1.482	<.001	<.001	3	27
KICH	LEF1-AS1 →	+0.769	+0.080	<.001	<.001	3	26
SARC	FGFR2 →	+1.733	+0.097	<.001	<.001	3	24
TGCT	WWTR1 →	+1.531	+0.079	<.001	<.001	3	23
THYM	SNED1 →	+1.440	+0.077	<.001	<.001	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071865 vs LEF1 — ACC

Explore this scatter interactively →