Regulation of apoptotic process in bone marrow cell

Across TCGA patient cohorts, RNA activity of the Regulation of apoptotic process in bone marrow cell pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NXNL2, KIAA1755, and RPL31P60, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of apoptotic process in bone marrow cell activity versus NXNL2 in HNSC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NXNL2 →	+0.292	+0.195	.001	.002	3	3
HNSC	KIAA1755 →	+1.247	+0.235	<.001	<.001	3	3
HNSC	RPL31P60 →	+1.132	+0.188	<.001	<.001	3	3
UCEC	GRK3 →	+0.615	+0.600	<.001	<.001	3	3
UCEC	LAP3 →	+1.186	+0.743	.007	.005	3	3
LSCC	KRT18P11 →	-0.585	-0.288	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071865 vs NXNL2 — HNSC

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