Regulation of apoptotic process in bone marrow cell

Across TCGA cell cohorts, RNA activity of the Regulation of apoptotic process in bone marrow cell pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTH, FGFR2, and LEF1, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTH grouped by Regulation of apoptotic process in bone marrow cell-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTH →	-0.299	-1.645	<.001	<.001	3	12
BREAST	FGFR2 →	-0.294	-1.111	.002	<.001	3	10
LARGE_INTESTINE	LEF1 →	-0.307	-1.163	<.001	.001	3	9
OVARY	PLK2 →	-0.296	-1.576	<.001	<.001	3	9
LIVER	CRABP1 →	-0.278	-1.732	.001	<.001	3	4
PANCREAS	RAB20 →	+0.197	+1.086	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTH by Regulation of apoptotic process in bone marrow cell activity — CNS

Explore this box plot interactively →