Positive regulation of cell proliferation in bone marrow

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation in bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1E2, YPEL5, and TCP11L2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AKR1E2 grouped by Positive regulation of cell proliferation in bone marrow-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AKR1E2 →	+1.953	+1.331	.004	.003	3	4
BLOOD_Leukemia	YPEL5 →	+0.906	+1.282	.001	.003	2	5
BLOOD_Leukemia	TCP11L2 →	+0.887	+1.067	.002	.003	3	4
BLOOD_Leukemia	AGPAT2 →	-1.099	-1.177	.001	.001	3	4
BLOOD_Leukemia	PRTFDC1 →	+2.586	+1.275	.001	.003	3	4
PANCREAS	KLHL24 →	+1.358	+1.225	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AKR1E2 by Positive regulation of cell proliferation in bone marrow activity — BONE

Explore this box plot interactively →