Positive regulation of cell proliferation in bone marrow

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation in bone marrow pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGA2, SHC1, and LEF1, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cell proliferation in bone marrow activity versus HMGA2 in LUNG_NSCLC_LUSC (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HMGA2 →	+2.246	+0.266	.003	<.001	3	11
LUNG_SCLC	SHC1 →	+1.526	+0.340	<.001	<.001	3	8
SOFT_TISSUE	LEF1 →	-2.415	-0.258	<.001	<.001	3	8
LIVER	FGFR2 →	-3.180	-0.264	<.001	.001	2	8
LARGE_INTESTINE	SMARCA1 →	+1.872	+0.168	<.001	<.001	3	6
LUNG_NSCLC_LUAD	DUSP8 →	-1.082	-0.179	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071864 vs HMGA2 — LUNG_NSCLC_LUSC

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