Positive regulation of cell proliferation in bone marrow

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell proliferation in bone marrow pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP93, SLC2A9, and ZBTB24, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NUP93 grouped by Positive regulation of cell proliferation in bone marrow-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NUP93 →	+0.371	+0.625	.001	<.001	3	1
SKIN	SLC2A9 →	+0.115	+0.583	.009	.002	3	1
SKIN	ZBTB24 →	+0.109	+0.733	.002	.009	3	1
SKIN	UTP25 →	-0.154	-0.625	<.001	<.001	3	1
SKIN	SLC17A1 →	+0.195	+0.625	<.001	<.001	3	1
SKIN	IL22 →	-0.224	-0.625	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NUP93 by Positive regulation of cell proliferation in bone marrow activity — SKIN

Explore this box plot interactively →