Apoptotic process in bone marrow cell

pathway activity — cross-omics
GO:0071839Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Apoptotic process in bone marrow cell pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LEF1, MT1G, and VCAN-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMLEF1 →+1.253+0.322<.001.00224
BRCAMT1G →-2.001-0.992.002<.00133
LUADVCAN-AS1 →+1.321+0.126.001<.00133
LSCCP2RX4 →-0.380-0.683<.001<.00133
LSCCRN7SL518P →-0.484-0.378.001.00933
LUADSTRA6 →+1.577+0.108.002<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration