Tail-anchored membrane protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Tail-anchored membrane protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOC6B, PROS1, and ASPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tail-anchored membrane protein insertion into ER membrane activity versus EXOC6B in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EXOC6B →	-0.369	-0.117	<.001	.009	3	5
UCEC	PROS1 →	-0.696	-0.175	<.001	<.001	3	5
LUAD	ASPA →	-0.470	-0.190	<.001	<.001	3	5
LUAD	PLSCR4 →	-0.572	-0.141	<.001	.002	3	5
PDAC	TRPC4 →	-0.424	-0.194	.004	.002	3	5
LUAD	ADH1B →	-1.136	-0.152	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071816 vs EXOC6B — GBM

Explore this scatter interactively →