Tail-anchored membrane protein insertion into ER membrane

Across TCGA cell cohorts, RNA activity of the Tail-anchored membrane protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DAZAP1, IKBKG, and SMIM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tail-anchored membrane protein insertion into ER membrane activity versus DAZAP1 in BREAST (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DAZAP1 →	+0.319	+0.158	.005	.003	3	5
UPPER_AERODIGESTIVE_TRACT	IKBKG →	+1.044	+0.261	<.001	.001	3	5
LIVER	SMIM7 →	+0.565	+0.245	.007	.001	2	5
BLOOD_Leukemia	NFIL3 →	+0.935	+0.144	.002	.004	3	4
STOMACH	CARS1 →	+1.070	+0.122	.002	.002	2	5
STOMACH	CIB2 →	-3.069	-0.123	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071816 vs DAZAP1 — BREAST

Explore this scatter interactively →