Protein transmembrane transport

Across TCGA patient cohorts, RNA activity of the Protein transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, PA2G4, and TNKS1BP1_S1073, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein transmembrane transport activity versus UCHL1 in LSCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UCHL1 →	+0.652	+0.022	.003	<.001	3	5
GBM	PA2G4 →	-0.288	-0.033	.001	<.001	3	5
LSCC	TNKS1BP1_S1073 →	-0.506	-0.036	.003	<.001	3	4
LSCC	ITGB4_T1530 →	-1.042	-0.030	<.001	.004	3	4
HNSC	LAD1 →	-0.534	-0.049	.001	.002	3	4
HNSC	LIMA1_S609 →	-0.468	-0.039	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071806 vs UCHL1 — LSCC

Explore this scatter interactively →