Positive regulation of podosome assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of podosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM61, APOL1, and ADCY7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of podosome assembly activity versus TRIM61 in LUAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM61 →	+0.538	+0.115	<.001	<.001	3	4
LSCC	APOL1 →	+1.027	+0.144	.003	.004	3	3
LSCC	ADCY7 →	+0.510	+0.150	.003	.004	3	3
UCEC	IRF5 →	+0.663	+0.236	.006	.002	2	4
LSCC	MSN →	+0.493	+0.129	.002	.004	3	3
LSCC	GSAP →	+0.348	+0.117	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071803 vs TRIM61 — LUAD

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