Positive regulation of podosome assembly

Across TCGA cell cohorts, RNA activity of the Positive regulation of podosome assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL4, CIZ1, and ACACA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL4 grouped by Positive regulation of podosome assembly-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	METTL4 →	-0.123	-0.276	.003	.004	3	5
BREAST	CIZ1 →	-0.160	-1.125	.003	<.001	3	4
KIDNEY	ACACA →	-0.199	-0.215	.003	.008	3	4
OESOPHAGUS	CDH20 →	-0.147	-0.322	<.001	<.001	3	4
BREAST	TRPS1 →	-0.208	-0.845	.004	.004	3	3
BREAST	HNRNPL →	+0.247	+0.894	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL4 by Positive regulation of podosome assembly activity — OESOPHAGUS

Explore this box plot interactively →