Podosome assembly

Across TCGA patient cohorts, RNA activity of the Podosome assembly pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, NCKAP1L, and IL4I1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Podosome assembly activity versus APBB1IP in GBM (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APBB1IP →	+0.562	+0.086	<.001	<.001	3	7
GBM	NCKAP1L →	+0.617	+0.086	<.001	<.001	3	7
GBM	IL4I1 →	+0.708	+0.069	<.001	<.001	3	7
HNSC	TAGAP_S400 →	+0.468	+0.063	.008	<.001	3	6
GBM	WDFY4 →	+0.402	+0.083	<.001	<.001	3	6
UCEC	DOCK10 →	+0.350	+0.061	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071800 vs APBB1IP — GBM

Explore this scatter interactively →