Podosome assembly

Across TCGA cell cohorts, RNA activity of the Podosome assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SH3PXD2B, FARP2, and HDLBP, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Podosome assembly activity versus SH3PXD2B in KIDNEY (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SH3PXD2B →	+1.861	+0.184	<.001	.001	2	14
SKIN	FARP2 →	+1.299	+0.141	<.001	<.001	3	12
OVARY	HDLBP →	+0.884	+0.149	<.001	.003	3	10
BREAST	STK25 →	+0.898	+0.156	<.001	.002	3	9
OVARY	THAP4 →	+0.954	+0.186	<.001	<.001	3	8
BREAST	FAM168B →	+0.704	+0.122	.006	.006	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071800 vs SH3PXD2B — KIDNEY

Explore this scatter interactively →