Response to prostaglandin D

Across TCGA patient cohorts, RNA activity of the Response to prostaglandin D pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C2, AKR1C3, and AKR1B10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin D activity versus AKR1C2 in UCEC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C2 →	+2.057	+0.258	<.001	<.001	3	7
LSCC	AKR1C3 →	+1.687	+0.312	<.001	<.001	3	7
LUAD	AKR1B10 →	+2.402	+0.187	<.001	<.001	3	5
LSCC	AKR1C1 →	+1.580	+0.288	<.001	<.001	3	5
LSCC	AKR1C3_S129 →	+1.897	+0.241	<.001	<.001	3	5
LUAD	G6PD →	+0.669	+0.201	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071798 vs AKR1C2 — UCEC

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