Response to prostaglandin D

Across TCGA cell cohorts, RNA activity of the Response to prostaglandin D pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1C1, AKR1C3, and AKR1C2, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to prostaglandin D activity versus AKR1C1 in LUNG_NSCLC_LUSC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AKR1C1 →	+7.247	+1.157	<.001	<.001	3	18
LUNG_NSCLC_LUSC	AKR1C3 →	+6.286	+1.188	<.001	<.001	3	18
LUNG_NSCLC_LUSC	AKR1C2 →	+7.556	+1.211	<.001	<.001	3	17
LIVER	AKR1B10 →	+8.858	+1.533	<.001	.001	3	13
URINARY_TRACT	ABCC3 →	+3.393	+1.089	<.001	.002	2	11
LUNG_NSCLC_LUSC	CYP4F11 →	+4.519	+1.135	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071798 vs AKR1C1 — LUNG_NSCLC_LUSC

Explore this scatter interactively →