Endoplasmic reticulum tubular network formation

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum tubular network formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATAD1, TRUB1, and DOCK11, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum tubular network formation activity versus ATAD1 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATAD1 →	+0.360	+0.055	<.001	<.001	3	9
LSCC	TRUB1 →	+0.307	+0.052	<.001	<.001	3	7
LUAD	DOCK11 →	-0.320	-0.077	<.001	<.001	3	7
LUAD	ERLIN1 →	+0.298	+0.047	<.001	<.001	3	7
BRCA	SNX29 →	-0.158	-0.031	<.001	.007	3	6
BRCA	SUPV3L1 →	+0.362	+0.060	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071787 vs ATAD1 — BRCA

Explore this scatter interactively →