Endoplasmic reticulum tubular network formation

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum tubular network formation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RX7, RTN1, and SPN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum tubular network formation activity versus P2RX7 in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	P2RX7 →	+0.543	+0.693	<.001	<.001	3	7
GBM	RTN1 →	+1.028	+0.866	<.001	<.001	3	6
PDAC	SPN →	+0.591	+0.780	<.001	<.001	3	6
PDAC	EBI3 →	+0.452	+0.519	<.001	<.001	3	5
GBM	DOCK10 →	+0.488	+0.775	<.001	<.001	3	5
GBM	ANKRD44 →	+0.560	+0.943	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071787 vs P2RX7 — GBM

Explore this scatter interactively →