Endoplasmic reticulum tubular network formation

Across TCGA cell cohorts, RNA activity of the Endoplasmic reticulum tubular network formation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MOB3C, RPS24, and CDRT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MOB3C grouped by Endoplasmic reticulum tubular network formation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MOB3C →	-1.018	-0.620	.005	.001	3	4
BREAST	RPS24 →	+1.173	+0.740	.003	.005	3	4
SKIN	CDRT1 →	-0.630	-0.341	.003	<.001	3	4
BONE	PRMT6 →	+0.792	+2.003	.009	<.001	3	3
BONE	PGC →	+0.559	+2.003	<.001	<.001	3	3
OESOPHAGUS	NBEA →	-1.736	-0.400	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MOB3C by Endoplasmic reticulum tubular network formation activity — STOMACH

Explore this box plot interactively →