Response to fibroblast growth factor

Across TCGA patient cohorts, RNA activity of the Response to fibroblast growth factor pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, CALHM5, and SRPX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to fibroblast growth factor activity versus SPARC in COAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SPARC →	+1.001	+0.188	<.001	<.001	3	6
COAD	CALHM5 →	+0.692	+0.181	<.001	<.001	3	6
COAD	SRPX →	+1.177	+0.187	<.001	<.001	3	5
COAD	CCN4 →	+0.955	+0.155	<.001	.002	3	5
CCRCC	FNDC4 →	+0.766	+0.428	.001	.002	3	5
COAD	CNRIP1 →	+0.711	+0.175	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071774 vs SPARC — COAD

Explore this scatter interactively →