Response to fibroblast growth factor

Across TCGA cell cohorts, RNA activity of the Response to fibroblast growth factor pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN11, SOX30, and ABHD17B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN11 grouped by Response to fibroblast growth factor-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTPN11 →	-0.415	-0.689	<.001	<.001	3	7
LUNG_NSCLC_LUAD	SOX30 →	-0.166	-0.444	.004	.008	3	6
KIDNEY	ABHD17B →	+0.363	+0.880	<.001	.009	3	4
LUNG_NSCLC_LUAD	GRB2 →	-0.309	-0.563	<.001	.004	3	4
CNS	MAP3K1 →	-0.126	-0.591	.005	.002	3	4
UPPER_AERODIGESTIVE_TRACT	NPHP4 →	-0.212	-0.336	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN11 by Response to fibroblast growth factor activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →