Response to fibroblast growth factor

Across TCGA cell cohorts, RNA activity of the Response to fibroblast growth factor pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are U2AF1L4, SLC27A1, and CHD1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, U2AF1L4 grouped by Response to fibroblast growth factor-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	U2AF1L4 →	+0.807	+0.940	.005	.004	2	5
KIDNEY	SLC27A1 →	+0.791	+0.985	.006	.003	3	3
KIDNEY	CHD1L →	-0.787	-1.262	<.001	<.001	2	4
KIDNEY	RSL24D1 →	-0.587	-1.037	.002	.003	3	3
SOFT_TISSUE	SMAD7 →	-2.361	-1.253	.002	.001	2	4
SOFT_TISSUE	CREB3L2 →	-1.314	-1.036	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

U2AF1L4 by Response to fibroblast growth factor activity — LARGE_INTESTINE

Explore this box plot interactively →