Response to BMP

Across TCGA patient cohorts, RNA activity of the Response to BMP pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, VCAN_S2116, and BGN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to BMP activity versus SERPINF1 in OV (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINF1 →	+0.808	+0.037	<.001	<.001	3	10
PDAC	VCAN_S2116 →	+1.154	+0.028	<.001	.002	3	9
BRCA	BGN →	+0.776	+0.031	<.001	<.001	3	9
LSCC	AEBP1 →	+0.722	+0.032	<.001	<.001	3	9
PDAC	LUM →	+0.824	+0.035	<.001	<.001	3	9
OV	PCOLCE →	+0.736	+0.028	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071772 vs SERPINF1 — OV

Explore this scatter interactively →