Response to BMP

Across TCGA patient cohorts, RNA activity of the Response to BMP pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM3, RWDD3, and POGLUT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to BMP activity versus SMIM3 in OV (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMIM3 →	+1.241	+0.830	<.001	<.001	3	5
GBM	RWDD3 →	+0.563	+0.966	.002	.001	3	5
PDAC	POGLUT2 →	+0.490	+0.185	<.001	<.001	3	5
GBM	ADAMTS6 →	+1.015	+1.102	<.001	<.001	3	5
PDAC	PCNX4 →	+0.193	+0.133	.006	.002	3	5
OV	FSTL1 →	+0.844	+0.474	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071772 vs SMIM3 — OV

Explore this scatter interactively →