Response to BMP

Across TCGA cell cohorts, RNA activity of the Response to BMP pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRD5A3, IFRD2, and ABHD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SRD5A3 grouped by Response to BMP-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SRD5A3 →	-1.038	-0.215	.006	.003	3	5
LARGE_INTESTINE	IFRD2 →	+0.480	+0.384	.005	.006	3	4
BREAST	ABHD11 →	-1.283	-0.497	<.001	.002	3	4
BREAST	RHPN1 →	-2.322	-0.521	<.001	.004	3	4
BREAST	GDPGP1 →	-0.626	-0.452	.006	.007	3	4
BREAST	SPPL2B →	-1.139	-0.197	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SRD5A3 by Response to BMP activity — BREAST

Explore this box plot interactively →