Response to BMP

Across TCGA cell cohorts, RNA activity of the Response to BMP pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K20, ZEB1, and OVOL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to BMP activity versus MAP3K20 in OESOPHAGUS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MAP3K20 →	-1.158	-1.149	.009	.008	3	5
LUNG_NSCLC_LUAD	ZEB1 →	-1.650	-0.913	<.001	.001	3	5
OVARY	OVOL2 →	+2.564	+1.127	<.001	<.001	3	5
OVARY	ZEB2 →	-2.176	-0.975	.001	.005	3	5
OVARY	CEP57L1 →	-0.916	-1.510	<.001	<.001	3	5
SOFT_TISSUE	CLCC1 →	-0.801	-1.434	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071772 vs MAP3K20 — OESOPHAGUS

Explore this scatter interactively →