Response to BMP

Across TCGA cell cohorts, RNA activity of the Response to BMP pathway is significantly associated with the protein abundance of multiple proteins, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZYX, TLN1, and ARPC5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to BMP activity versus ZYX in OESOPHAGUS (Pearson r = -0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ZYX →	-2.541	-1.223	.001	.001	3	7
URINARY_TRACT	TLN1 →	-1.981	-0.793	.001	.005	3	7
OVARY	ARPC5 →	-1.082	-0.966	<.001	<.001	3	7
OVARY	TXN →	-1.706	-0.796	.001	.006	3	7
OVARY	WDR1 →	-1.205	-0.769	<.001	.001	3	7
URINARY_TRACT	TPD52L2 →	-1.291	-0.792	.009	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071772 vs ZYX — OESOPHAGUS

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