Response to nitric oxide

Across TCGA patient cohorts, RNA activity of the Response to nitric oxide pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMEM87A_S475, ARHGEF6_S684, and CLIC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nitric oxide activity versus TMEM87A_S475 in PDAC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TMEM87A_S475 →	-0.535	-0.041	.001	<.001	3	6
LSCC	ARHGEF6_S684 →	+0.592	+0.049	.003	.002	3	6
BRCA	CLIC2 →	+0.461	+0.050	<.001	<.001	3	6
BRCA	ANKRD44 →	+0.401	+0.055	<.001	<.001	3	6
COAD	FLNA →	+0.559	+0.040	<.001	<.001	3	5
OV	GIMAP1 →	+0.345	+0.045	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071731 vs TMEM87A_S475 — PDAC

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