Response to nitric oxide

Across TCGA patient cohorts, RNA activity of the Response to nitric oxide pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKD1, MRC2, and COL6A3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nitric oxide activity versus PRKD1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKD1 →	+0.524	+0.166	<.001	.001	3	5
BRCA	MRC2 →	+0.641	+0.145	.001	.006	3	4
BRCA	COL6A3 →	+0.892	+0.139	<.001	.008	3	4
BRCA	MRGPRF →	+0.535	+0.152	<.001	.003	3	4
UCEC	MYLK →	+0.791	+0.165	.004	.003	3	4
CCRCC	PLA2G4C →	+0.461	+0.109	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071731 vs PRKD1 — BRCA

Explore this scatter interactively →