Response to nitric oxide

Across TCGA cell cohorts, RNA activity of the Response to nitric oxide pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDK2, CCNA2, and CDC25B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDK2 grouped by Response to nitric oxide-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDK2 →	-0.543	-0.220	.003	.004	3	8
BREAST	CCNA2 →	-0.376	-0.353	<.001	<.001	3	5
BREAST	CDC25B →	-0.351	-0.300	<.001	<.001	3	4
LUNG_SCLC	ATP5F1A →	-0.302	-0.275	.009	<.001	3	4
BREAST	DDB1 →	-0.235	-0.231	.002	.006	3	4
LUNG_NSCLC_LUAD	HOXB1 →	+0.083	+0.190	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK2 by Response to nitric oxide activity — BREAST

Explore this box plot interactively →