Response to nitric oxide

Across TCGA cell cohorts, RNA activity of the Response to nitric oxide pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MXD3, PALLD, and AIFM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nitric oxide activity versus MXD3 in BLOOD_Leukemia (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MXD3 →	-1.795	-0.179	<.001	<.001	3	5
OESOPHAGUS	PALLD →	-1.408	-0.182	.002	.008	3	5
BLOOD_Lymphoma	AIFM1 →	+0.959	+0.142	<.001	.009	3	5
BLOOD_Leukemia	LACC1 →	+0.692	+0.117	.005	<.001	3	5
STOMACH	RNF113A →	+0.712	+0.115	.001	.006	3	4
KIDNEY	NPDC1 →	+2.356	+0.163	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071731 vs MXD3 — BLOOD_Leukemia

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