Response to diacyl bacterial lipopeptide

Across TCGA patient cohorts, RNA activity of the Response to diacyl bacterial lipopeptide pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM20A, CD86, and PLEK, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to diacyl bacterial lipopeptide activity versus FAM20A in OV (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FAM20A →	+1.296	+0.088	.003	.004	3	8
OV	CD86 →	+1.018	+0.114	<.001	<.001	3	8
HNSC	PLEK →	+1.075	+0.115	.003	<.001	3	8
HNSC	TYROBP →	+1.128	+0.092	<.001	.002	3	8
OV	PLAU →	+1.322	+0.121	<.001	<.001	3	8
GBM	SIGLEC9 →	+1.043	+0.136	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071724 vs FAM20A — OV

Explore this scatter interactively →