Response to diacyl bacterial lipopeptide

Across TCGA cell cohorts, RNA activity of the Response to diacyl bacterial lipopeptide pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CBR1, SQSTM1, and CANX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to diacyl bacterial lipopeptide activity versus CBR1 in LUNG_NSCLC_LUAD (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CBR1 →	+1.599	+0.917	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SQSTM1 →	+1.208	+0.531	.005	.006	2	5
BLOOD_Leukemia	CANX →	+0.596	+1.068	<.001	<.001	3	4
LUNG_NSCLC_LUAD	IDH3G →	+0.767	+0.928	.002	<.001	2	4
LUNG_SCLC	TM9SF4 →	+0.925	+0.532	<.001	.007	3	3
UPPER_AERODIGESTIVE_TRACT	SRSF11 →	-1.798	-1.483	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071724 vs CBR1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →