Icosanoid transport

Across TCGA cell cohorts, RNA activity of the Icosanoid transport pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALS2CL, CGB5, and MARS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Icosanoid transport activity versus ALS2CL in PANCREAS (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ALS2CL →	+2.389	+1.499	.001	<.001	3	7
LARGE_INTESTINE	CGB5 →	+0.391	+0.849	.003	.008	2	6
LARGE_INTESTINE	MARS2 →	-0.900	-1.468	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	DARS2 →	-0.939	-1.298	<.001	.002	3	5
SKIN	XPO4 →	-0.774	-1.071	.002	.001	3	5
OESOPHAGUS	COG2 →	-0.468	-0.962	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071715 vs ALS2CL — PANCREAS

Explore this scatter interactively →