Basement membrane organization

Across TCGA patient cohorts, RNA activity of the Basement membrane organization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF1, SRPX2, and THBS2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basement membrane organization activity versus SERPINF1 in BRCA (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPINF1 →	+0.992	+0.055	<.001	<.001	3	10
BRCA	SRPX2 →	+0.922	+0.053	<.001	<.001	3	10
CCRCC	THBS2 →	+1.190	+0.064	<.001	<.001	3	10
BRCA	TIMP3 →	+0.873	+0.057	<.001	<.001	3	10
OV	VCL_Y822 →	+1.213	+0.079	<.001	<.001	3	10
UCEC	BGN →	+1.067	+0.097	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071711 vs SERPINF1 — BRCA

Explore this scatter interactively →