Basement membrane organization

Across TCGA patient cohorts, RNA activity of the Basement membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAM3, TCEAL7, and CALD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basement membrane organization activity versus JAM3 in BRCA (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	JAM3 →	+0.879	+0.250	<.001	<.001	3	8
OV	TCEAL7 →	+1.027	+0.277	<.001	.001	3	8
COAD	CALD1 →	+1.125	+0.245	<.001	.004	3	7
OV	TGFB1I1 →	+0.897	+0.282	<.001	<.001	3	7
LSCC	GUCY1A2 →	+0.778	+0.308	<.001	<.001	3	7
OV	CYGB →	+0.779	+0.245	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071711 vs JAM3 — BRCA

Explore this scatter interactively →