Basement membrane organization

Across TCGA cell cohorts, RNA activity of the Basement membrane organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARS2, CHAF1A, and DCTPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Basement membrane organization activity versus LARS2 in PANCREAS (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	LARS2 →	-1.151	-0.213	<.001	<.001	3	4
LIVER	CHAF1A →	-0.979	-0.251	.005	<.001	3	4
LUNG_SCLC	DCTPP1 →	-0.705	-0.978	.003	.002	3	4
LUNG_NSCLC_LUAD	UQCRC1 →	-0.488	-0.172	<.001	.003	2	5
BLOOD_Lymphoma	LRP10 →	+1.527	+0.977	<.001	<.001	3	4
SKIN	MRPL4 →	-0.858	-0.946	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071711 vs LARS2 — PANCREAS

Explore this scatter interactively →