Ectodermal placode development

Across TCGA patient cohorts, RNA activity of the Ectodermal placode development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HMGB3, NONO, and PTPN7_S149, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectodermal placode development activity versus HMGB3 in HNSC (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HMGB3 →	+0.480	+0.064	<.001	.002	3	5
COAD	NONO →	+0.147	+0.057	.005	.001	3	5
BRCA	PTPN7_S149 →	-0.522	-0.051	<.001	<.001	3	5
BRCA	EFHD1 →	+0.809	+0.078	<.001	<.001	3	5
LSCC	FGD2_S654 →	-0.601	-0.069	<.001	.005	3	5
BRCA	ZFHX3_S3432 →	+0.483	+0.061	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071696 vs HMGB3 — HNSC

Explore this scatter interactively →