Ectodermal placode development

Across TCGA patient cohorts, RNA activity of the Ectodermal placode development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMYD3-IT1, TBX2, and NAGA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectodermal placode development activity versus SMYD3-IT1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SMYD3-IT1 →	+0.184	+0.983	<.001	<.001	3	4
CCRCC	TBX2 →	+0.876	+0.193	.002	.001	3	3
PDAC	NAGA →	-0.279	-0.481	.003	.001	3	3
UCEC	TBX3 →	+1.037	+0.643	.001	<.001	3	3
CCRCC	ABCG2 →	+0.730	+0.187	.004	<.001	3	3
CCRCC	APOC1 →	-1.423	-0.235	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071696 vs SMYD3-IT1 — OV

Explore this scatter interactively →