Ectodermal placode development

Across TCGA cell cohorts, RNA activity of the Ectodermal placode development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTSSB, NME7, and CUTA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPTSSB grouped by Ectodermal placode development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPTSSB →	+4.145	+0.762	<.001	.004	3	4
SOFT_TISSUE	NME7 →	-1.641	-1.344	<.001	.002	3	4
OVARY	CUTA →	-0.592	-0.556	<.001	.004	3	4
CNS	NMNAT2 →	-1.619	-0.840	<.001	<.001	3	4
OESOPHAGUS	POR →	-0.775	-0.590	<.001	.009	3	4
BLOOD_Leukemia	ZNF331 →	+1.474	+0.322	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPTSSB by Ectodermal placode development activity — BREAST

Explore this box plot interactively →