Ectodermal placode development

Across TCGA cell cohorts, RNA activity of the Ectodermal placode development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL3, TMEM44, and RNF168, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ectodermal placode development activity versus BCL3 in BLOOD_Leukemia (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCL3 →	-1.307	-0.735	.004	.001	3	4
BLOOD_Leukemia	TMEM44 →	+1.169	+0.974	<.001	<.001	3	4
BLOOD_Leukemia	RNF168 →	+1.249	+1.101	<.001	<.001	3	4
BLOOD_Leukemia	PIGX →	+0.702	+0.651	.001	.008	3	4
BLOOD_Leukemia	OTUD3 →	+0.686	+0.760	.002	<.001	3	4
BLOOD_Leukemia	CAMK1D →	+1.676	+0.947	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071696 vs BCL3 — BLOOD_Leukemia

Explore this scatter interactively →