Anatomical structure maturation

Across TCGA patient cohorts, RNA activity of the Anatomical structure maturation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLM, AP3S1, and GARS1-DT, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anatomical structure maturation activity versus POLM in COAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POLM →	+0.357	+0.534	.007	.003	3	3
COAD	AP3S1 →	-0.484	-0.745	.001	<.001	3	3
COAD	GARS1-DT →	+0.263	+0.389	.003	.009	3	3
PDAC	CHPT1 →	-0.780	-0.896	<.001	.001	3	3
PDAC	HNRNPA1P5 →	-0.455	-1.014	<.001	<.001	3	3
OV	TTC33 →	-0.360	-0.168	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071695 vs POLM — COAD

Explore this scatter interactively →