Organism emergence from protective structure

pathway activity — cross-omics
GO:0071684Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Organism emergence from protective structure pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD34, TNS2_S941, and ARHGAP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCD34 →-0.677-0.044<.001<.00136
PDACTNS2_S941 →-0.299-0.034<.001<.00136
CCRCCARHGAP6 →-0.182-0.028<.001.00336
HNSCPLCD1 →-0.615-0.072<.001<.00135
CCRCCTNS2 →-0.323-0.031<.001.00435
CCRCCFOLR2 →-0.540-0.043.001.00435
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration