Cellular response to indole-3-methanol

Across TCGA patient cohorts, RNA activity of the Cellular response to indole-3-methanol pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EFHD1, ARVCF_S335, and WDR36, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to indole-3-methanol activity versus EFHD1 in COAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EFHD1 →	+0.657	+0.038	.007	.001	3	6
BRCA	ARVCF_S335 →	+0.833	+0.088	<.001	<.001	3	5
OV	WDR36 →	-0.227	-0.066	.005	.005	3	5
LUAD	CCDC6_S52 →	-0.942	-0.034	<.001	<.001	3	5
LUAD	CDC20_T106 →	-1.374	-0.051	<.001	<.001	3	5
LSCC	CGAS →	-0.456	-0.026	.003	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071681 vs EFHD1 — COAD

Explore this scatter interactively →